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2-oxoadipate reductase

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2-oxoadipate reductase
Identifiers
EC no.1.1.1.172
CAS no.61116-21-0
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IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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In enzymology, a 2-oxoadipate reductase (EC 1.1.1.172) is an enzyme that catalyzes the chemical reaction

2-hydroxyadipate + NAD+ 2-oxoadipate + NADH + H+

Thus, the two substrates of this enzyme are 2-hydroxyadipate and NAD+, whereas its 3 products are 2-oxoadipate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-hydroxyadipate:NAD+ 2-oxidoreductase. Other names in common use include 2-ketoadipate reductase, alpha-ketoadipate reductase, and 2-ketoadipate reductase.

References

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  • Suda T, Robinson JC, Fjellstedt TA (1976). "Purification and properties of alpha-ketoadipate reductase, a newly discovered enzyme from human placenta". Arch. Biochem. Biophys. 176 (2): 610–20. doi:10.1016/0003-9861(76)90205-8. PMID 185965.