3(or 17)a-hydroxysteroid dehydrogenase

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3(or 17)alpha-hydroxysteroid dehydrogenase
Identifiers
EC number 1.1.1.209
CAS number 83294-77-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3(or 17)alpha-hydroxysteroid dehydrogenase (EC 1.1.1.209, 3(17)alpha-hydroxysteroid dehydrogenase) is an enzyme with systematic name 3(or 17)alpha-hydroxysteroid:NAD(P)+ oxidoreductase.[1][2] This enzyme catalyses the chemical reaction

androsterone + NAD(P)+ 5alpha-androstane-3,17-dione + NAD(P)H + H+

This enzyme acts on the 3alpha-hydroxy group of androgens of the 5alpha-androstane series; and also, more slowly, on the 17alpha-hydroxy group of both androgenic and estrogenic substrates (cf. EC 1.1.1.51 3(or 17)beta-hydroxysteroid dehydrogenase).

References[edit]

  1. ^ Lau, P.C.K.; Layne, D.S.; Williamson, D.G. (1982). "A 3(17)α-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme". J. Biol. Chem. 257: 9444–9449. PMID 6955302. 
  2. ^ Lau, P.C.K.; Layne, D.S.; Williamson, D.G. (1982). "Comparison of the multiple forms of the soluble 3(17)α-hydroxysteroid dehydrogenases of female rabbit kidney and liver". J. Biol. Chem. 257: 9450–9456. PMID 6955303. 

External links[edit]