3-hydroxypropionate dehydrogenase

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3-hydroxypropionate dehydrogenase
Identifiers
EC number1.1.1.59
CAS number9028-59-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a 3-hydroxypropionate dehydrogenase (EC 1.1.1.59) is an enzyme that catalyzes the chemical reaction

3-hydroxypropanoate + NAD+ 3-oxopropanoate + NADH + H+

Thus, the two substrates of this enzyme are 3-hydroxypropanoate and NAD+, whereas its 3 products are 3-oxopropanoate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxypropanoate:NAD+ oxidoreductase. This enzyme participates in beta-alanine metabolism and propanoate metabolism.

References[edit]

  • Den H, Robinson WG, Coon MJ (1959). "Enzymatic conversion of beta-hydroxypropionate to malonic semialdehyde". J. Biol. Chem. 234 (7): 1666–1671. PMID 13672942.