Type XVIII collagen
| collagen, type XVIII, alpha 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | COL18A1 | ||||||
| NCBI gene | 80781 | ||||||
| HGNC | 2195 | ||||||
| OMIM | 120328 | ||||||
| RefSeq | NM_130445 | ||||||
| UniProt | P39060 | ||||||
| Other data | |||||||
| Locus | Chr. 21 q22.3 | ||||||
| |||||||
Type XVIII collagen is a type of collagen which can be cleaved to form endostatin. The endostatin is from the c terminus end of the collagen XVIII, and is known to have an inhibitory effect on the growth of blood vessels. This is seen with tumors, where endostatin inhibits the growth of the blood vessels of the tumor as well as the overall growth of the tumor. [1]
The collagen XVIII is located within the basement membrane, and plays a major role in the integrity of the structure of the basement membrane for both endothelial and epithelial cells.[2] The collagen XVIII has three different isoforms. While each of the isoforms has the same C-terminus end, they have a varying structure on the N-terminus end, which results in the formation of short, medium or long form Collagen XVIII. [3]
References
- ^ Heljasvaara R, Aikio M, Ruotsalainen H, Pihlajaniemi T (January 2017). "Collagen XVIII in tissue homeostasis and dysregulation - Lessons learned from model organisms and human patients". Matrix Biology. 57–58: 55–75. doi:10.1016/j.matbio.2016.10.002. PMID 27746220.
- ^ Rygh CB, Løkka G, Heljasvaara R, Taxt T, Pavlin T, Sormunen R, et al. (January 2014). "Image-based assessment of microvascular function and structure in collagen XV- and XVIII-deficient mice". The Journal of Physiology. 592 (2): 325–36. doi:10.1113/jphysiol.2013.263574. PMC 3922497. PMID 24218547.
- ^ Kinnunen AI, Sormunen R, Elamaa H, Seppinen L, Miller RT, Ninomiya Y, et al. (March 2011). "Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane". The Journal of Biological Chemistry. 286 (10): 7755–64. doi:10.1074/jbc.m110.166132. PMC 3048663. PMID 21193414.
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External links
- Collagen+Type+XVIII at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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