ALCAM

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ALCAM
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ALCAM, CD166, MEMD, activated leukocyte cell adhesion molecule
External IDs MGI: 1313266 HomoloGene: 1229 GeneCards: ALCAM
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001627
NM_001243280
NM_001243281
NM_001243283

NM_009655
NM_001331110

RefSeq (protein)

NP_001230209
NP_001230210
NP_001230212
NP_001618

NP_033785.1
NP_001318039
NP_033785

Location (UCSC) Chr 3: 105.37 – 105.58 Mb Chr 16: 52.25 – 52.45 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.[3][4] It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands. CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. Recently, CD166 has also been used as a potential cancer stem cell marker.


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U, et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med. 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054Freely accessible. PMID 7760007. 
  4. ^ "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule". 

Further reading[edit]

External links[edit]