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Activated leukocyte cell adhesion molecule
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ALCAM ; CD166; MEMD
External IDs OMIM601662 MGI1313266 HomoloGene1229 GeneCards: ALCAM Gene
Species Human Mouse
Entrez 214 11658
Ensembl ENSG00000170017 ENSMUSG00000022636
UniProt Q13740 Q61490
RefSeq (mRNA) NM_001243280 NM_009655
RefSeq (protein) NP_001230209 NP_033785
Location (UCSC) Chr 3:
105.37 – 105.58 Mb
Chr 16:
52.25 – 52.45 Mb
PubMed search [1] [2]

CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.[1][2] It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. Some literature sources have also cited it as the CD6 ligand (CD6L). It is expressed on activated T cells, activated monocytes, epithelial cells, fibroblasts, neurons, melanoma cells, and also in sweat and sebaceous glands. CD166 protein expression is reported to be upregulated in a cell line deriving from a metastasizing melanoma. CD166 plays an important role in mediating adhesion interactions between thymic epithelial cells and CD6+ cells during intrathymic T cell development. Recently, CD166 has also been used as a potential cancer stem cell marker.


  1. ^ Bowen MA, Patel DD, Li X, Modrell B, Malacko AR, Wang WC, Marquardt H, Neubauer M, Pesando JM, Francke U; et al. (Jun 1995). "Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand". J Exp Med 181 (6): 2213–20. doi:10.1084/jem.181.6.2213. PMC 2192054. PMID 7760007. 
  2. ^ "Entrez Gene: ALCAM activated leukocyte cell adhesion molecule". 

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