CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2gene.[5][6][7]
Function
CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of
gluconeogenicgene expression in response to cAMP.[8] CRTC2 is thought to drive tumorigenesis in LKB11/STK11-null non-small cell lung cancers (NSCLC).[9]
^ abScreaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID15454081.
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Screaton RA, Conkright MD, Katoh Y, Best JL, Canettieri G, Jeffries S, et al. (October 2004). "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell. 119 (1): 61–74. doi:10.1016/j.cell.2004.09.015. PMID15454081.