AKR1B10

AKR1B10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ZUA, 4GA8, 4GAB, 4GQ0, 4GQG, 4I5X, 4ICC, 4JIH, 4JII, 4WEV, 4XZL, 4XZN, 4XZM
Identifiers
Aliases	AKR1B10, AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI, aldo-keto reductase family 1, member B10 (aldose reductase), aldo-keto reductase family 1 member B10
External IDs	OMIM: 604707; MGI: 107673; HomoloGene: 116462; GeneCards: AKR1B10; OMA:AKR1B10 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	134,541,412 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	34,345,398 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; gums; ; gingival epithelium; ; mucosa of transverse colon; ; gallbladder; ; pancreatic ductal cell; ; gastric mucosa; ; islet of Langerhans; ; mucosa of sigmoid colon;
	Top expressed in
	pyloric antrum; ; mucous cell of stomach; ; adrenal gland; ; Scarpa's ganglion; ; epithelium of stomach; ; blastocyst; ; endothelial cell of lymphatic vessel; ; Gonadal ridge; ; stroma of bone marrow; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	retinal dehydrogenase activity; geranylgeranyl reductase activity; indanol dehydrogenase activity; aldo-keto reductase (NADP) activity; protein binding; oxidoreductase activity; alditol:NADP+ 1-oxidoreductase activity; alcohol dehydrogenase (NADP+) activity; NADP-retinol dehydrogenase activity; allyl-alcohol dehydrogenase activity;
Cellular component	cytosol; extracellular region; lysosome; mitochondrion;
Biological process	daunorubicin metabolic process; doxorubicin metabolic process; retinoid metabolic process; farnesol catabolic process; retinol metabolic process; cellular detoxification of aldehyde;
	Sources:Amigo / QuickGO
Orthologs
	57016
	14187
	ENSG00000198074
	ENSMUSG00000029762
	O60218
	P45377
	NM_020299
	NM_008012
	NP_064695
	NP_032038
	Wikidata
View/Edit Human	View/Edit Mouse

Aldo-keto reductase family 1 member B10 is an enzyme that in humans is encoded by the AKR1B10 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198074 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029762 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hyndman DJ, Flynn TG (Oct 1998). "Sequence and expression levels in human tissues of a new member of the aldo-keto reductase family". Biochim Biophys Acta. 1399 (2–3): 198–202. doi:10.1016/s0167-4781(98)00109-2. PMID 9765596.
^ Cao D, Fan ST, Chung SS (Jun 1998). "Identification and characterization of a novel human aldose reductase-like gene". J Biol Chem. 273 (19): 11429–35. doi:10.1074/jbc.273.19.11429. PMID 9565553.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)".

External links

Human AKR1B10 genome location and AKR1B10 gene details page in the UCSC Genome Browser.
Human ARL1 genome location and ARL1 gene details page in the UCSC Genome Browser.

v t e Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor	3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C4 7A2 Aldose reductase Beta-Ketoacyl ACP reductase Carbohydrate dehydrogenases Carnitine dehydrogenase D-malate dehydrogenase (decarboxylating) DXP reductoisomerase Glucose-6-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase HMG-CoA reductase IMP dehydrogenase Isocitrate dehydrogenase Lactate dehydrogenase L-threonine dehydrogenase L-xylulose reductase Malate dehydrogenase Malate dehydrogenase (decarboxylating) Malate dehydrogenase (NADP+) Malate dehydrogenase (oxaloacetate-decarboxylating) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Phosphogluconate dehydrogenase Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3β 3β-HSD NSDHL 11β 11β-HSD1 11β-HSD2 17β
1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) D-lactate dehydrogenase (cytochrome c-553) Mannitol dehydrogenase (cytochrome)
1.1.3: oxygen acceptor	Glucose oxidase L-gulonolactone oxidase Xanthine oxidase Alcohol oxidase
1.1.4: disulfide as acceptor	Vitamin K epoxide reductase Vitamin-K-epoxide reductase (warfarin-insensitive)
1.1.5: quinone/similar acceptor	Malate dehydrogenase (quinone) Quinoprotein glucose dehydrogenase
1.1.99: other acceptors	Choline dehydrogenase L2HGDH

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

External links

Further reading