Acetoacetyl-CoA reductase

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acetoacetyl-CoA reductase
Acetoacetyl-CoA reductase tetramer, Cupriavidus necator
EC no.
CAS no.9028-41-5
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an acetoacetyl-CoA reductase (EC is an enzyme that catalyzes the chemical reaction

(R)-3-hydroxyacyl-CoA + NADP+ 3-oxoacyl-CoA + NADPH + H+

Thus, the two substrates of this enzyme are (R)-3-hydroxyacyl-CoA and NADP+, whereas its 3 products are 3-oxoacyl-CoA, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase. Other names in common use include acetoacetyl coenzyme A reductase, hydroxyacyl coenzyme-A dehydrogenase, NADP+-linked acetoacetyl CoA reductase, NADPH:acetoacetyl-CoA reductase, D(−)-beta-hydroxybutyryl CoA-NADP+ oxidoreductase, short chain beta-ketoacetyl(acetoacetyl)-CoA reductase, beta-ketoacyl-CoA reductase, D-3-hydroxyacyl-CoA reductase, and (R)-3-hydroxyacyl-CoA dehydrogenase. This enzyme participates in butanoate metabolism.


  • Wakil S, Bressler R (March 1962). "Studies on the mechanism of fatty acid synthesis. X. Reduced triphosphopyridine nucleotide-acetoacetyl coenzyme A reductase". The Journal of Biological Chemistry. 237: 687–93. PMID 14004466.