Extended-spectrum penicillin

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The extended-spectrum penicillins are a group of antibiotics that have the widest antibacterial spectrum of all penicillins.[1] Some sources identify them with antipseudomonal penicillins,[2] others consider these types to be distinct.[3] This group includes the carboxypenicillins and the ureidopenicillins. Aminopenicillins, in contrast, do not have activity against Pseudomonas species, as their positively charged amino group does not hinder degradation by bacterially produced beta-lactamases.[4]

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  1. ^ Comprehensive Pharmacy Review, Leon Shargel, 6th edition, p917
  2. ^ Elsevier's Integrated Review Pharmacology, By Mark Kester, Kelly Dowhower Karpa, Kent E. Vrana, subclassification of penicillins section
  3. ^ edited by Michelle A. Clark, Richard A. Harvey, Richard Finkel, Jose A. Rey, Karen Whalen, p383
  4. ^ Golan, David E. Principles of Pharmacology (2 ed.). Lippincott Williams & Wilkins. p. 610. ISBN 1608312704.