Cefalotin

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Cefalotin
Cefalotin.svg
Clinical data
AHFS/Drugs.com International Drug Names
MedlinePlus a682860
Pregnancy
category
  • AU: A
  • US: B (No risk in non-human studies)
Routes of
administration
Intravenous
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability n/a
Protein binding 65 to 80%
Metabolism Hepatic
Biological half-life 30 minutes to 1 hour
Excretion Renal
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.005.288
Chemical and physical data
Formula C16H16N2O6S2
Molar mass 396.44 g/mol
3D model (Jmol)
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Cefalotin (INN) /ˌsɛfəˈltn/ or cephalothin (USAN) /ˌsɛfəˈlθn/ is a first-generation cephalosporin antibiotic.[1] It was the first cephalosporin marketed (1964) and continues to be widely used.[2] It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is marketed as Keflin (Lilly) and under other trade names.[3]

References[edit]

  1. ^ Hameed, T. K.; Robinson, J. L. (2002). "Review of the use of cephalosporins in children with anaphylactic reactions from penicillins". The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses. 13 (4): 253–8. PMC 2094874Freely accessible. PMID 18159398. 
  2. ^ David Greenwood (21 February 2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford. pp. 128–. ISBN 978-0-19-953484-5. 
  3. ^ International Drug Names: Cefalotin