Cook–Heilbron thiazole synthesis

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Cook-Heilbron thiazole synthesis
Named after Alan H. Cook
Ian Heilbron
Reaction type Ring forming reaction

The Cook–Heilbron thiazole synthesis is the chemical reaction of α-aminonitriles with carbon disulfide to form 5-amino-2-mercapto-thiazoles.[1] It is named after Alan H. Cook and Sir Ian Morris Heilbron.

The Cook-Heilbron thiazole synthesis


  1. ^ Cook, A. H.; Heilbron, I.; MacDonald, S. F.; Mahadevan, A. P. J. Chem. Soc. 1949, 1064.