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D-2-hydroxy-acid dehydrogenase

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D-2-hydroxy-acid dehydrogenase
Identifiers
EC no.1.1.99.6
CAS no.9028-83-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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In enzymology, a D-2-hydroxy-acid dehydrogenase (EC 1.1.99.6) is an enzyme that catalyzes the chemical reaction

(R)-lactate + acceptor pyruvate + reduced acceptor

Thus, the two substrates of this enzyme are (R)-lactate and acceptor, whereas its two products are pyruvate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (R)-2-hydroxy-acid:acceptor 2-oxidoreductase. Other names in common use include D-2-hydroxy acid dehydrogenase, and (R)-2-hydroxy-acid:(acceptor) 2-oxidoreductase. It has 2 cofactors: FAD, and Zinc.

References

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  • Gregolin C, Singer TP, Kearney EB, Boeri E (1961). "The formation and enzymatic properties of the various lactic dehydrogenases of yeast". Ann. N. Y. Acad. Sci. 94 (3): 780–97. Bibcode:1961NYASA..94..780G. doi:10.1111/j.1749-6632.1961.tb35573.x. PMID 13901630. S2CID 28665110.
  • Nygaard AP (1961). "D(−)-Lactate cytochrome c reductase, a flavoprotein from yeast". J. Biol. Chem. 236 (3): 920–925. doi:10.1016/S0021-9258(18)64331-5. PMID 13729965.
  • Tubbs PK; Greville GD (1959). "Dehydrogenation of D-lactate by a soluble enzyme from kidney mitochondria". Biochim. Biophys. Acta. 34: 290–291. doi:10.1016/0006-3002(59)90276-8. PMID 13839714.