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Dihydrocarveol dehydrogenase

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Dihydrocarveol dehydrogenase
Identifiers
EC no.1.1.1.296
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BRENDABRENDA entry
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Dihydrocarveol dehydrogenase (EC 1.1.1.296, carveol dehydrogenase (ambiguous)) is an enzyme with systematic name menth-8-en-2-ol:NAD+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

menth-8-en-2-ol + NAD+ menth-8-en-2-one + NADH + H+

This enzyme from the Gram-positive bacterium Rhodococcus erythropolis DCL14 forms part of the carveol and dihydrocarveol degradation pathway. The enzyme accepts all eight stereoisomers of menth-8-en-2-ol as substrate, although some isomers are converted faster than others. The preferred substrates are (+)-neoisodihydrocarveol, (+)-isodihydrocarveol, (+)-dihydrocarveol and (-)-isodihydrocarveol.

References

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  1. ^ van der Werf MJ, Boot AM (May 2000). "Metabolism of carveol and dihydrocarveol in Rhodococcus erythropolis DCL14". Microbiology. 146 ( Pt 5) (5): 1129–41. doi:10.1099/00221287-146-5-1129. PMID 10832640.
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