dnaD
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| Primosomal protein DnaD | |
|---|---|
| Identifiers | |
| Symbol | dnaI |
DnaD is a 232 amino acid long protein that is part of the primosome involved in prokaryotic DNA replication.[1] In Bacillus subtilis, genetic analysis has revealed three primosomal proteins, DnaB, DnaD, and DnaI, that have no obvious homologues in E. coli. They are involved in primosome function both at arrested replication forks and at the chromosomal origin.[2]
DnaB and DnaD proteins are both multimeric and bind individually to DNA. DnaD induces DnaB to bind. DnaD alone and the DnaD/DnaB complex then interact with PriA of Bacillus subtilis at several DNA sites. This suggests that the nucleoprotein assembly is sequential in the PriA, DnaD, DnaB order.[3]
References
- ^ Bruand, C.; Sorokin, A.; Serror, P.; Ehrlich, S. D. (1995). "Nucleotide sequence of the Bacillus subtilis dnaD gene". Microbiology. 141 (2): 321–2. doi:10.1099/13500872-141-2-321. PMID 7704260.
- ^ Ishigo-oka, D.; Ogasawara, N.; Moriya, S. (2001). "DnaD Protein of Bacillus subtilis Interacts with DnaA, the Initiator Protein of Replication". Journal of Bacteriology. 183 (6): 2148–50. doi:10.1128/JB.183.6.2148-2150.2001. PMC 95117. PMID 11222620.
- ^ Marsin, S.; McGovern, S.; Ehrlich, S. D.; Bruand, C.; Polard, P. (2001). "Early Steps of Bacillus subtilis Primosome Assembly". Journal of Biological Chemistry. 276 (49): 45818–25. doi:10.1074/jbc.M101996200. PMID 11585815.
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