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DNA polymerase III, delta subunit
Organism Escherichia coli
(str. K-12 substr. MG1655)
Symbol holA
Entrez 947573
RefSeq (Prot) NP_415173.1
UniProt P28630
Other data
EC number
Chromosome genome: 0.67 - 0.67 Mb
DNA polymerase III, delta subunit
PDB 1xxh EBI.jpg
atpgs bound e. coli clamp loader complex
Symbol DNA_pol3_delta
Pfam PF06144
Pfam clan CL0023
InterPro IPR010372
SCOP 1jql

In molecular biology, holA is a gene that encodes the δ (delta) subunit of DNA polymerase III in E. coli and other bacteria. Along with the γ, δ', χ, and ψ subunits that make up the core polymerase, and the β accessory proteins, the δ subunit is responsible for the high speed and processivity of polIII.[1][2]


  1. ^ Dong Z, Onrust R, Skangalis M, O'Donnell M (June 1993). "DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'" (PDF). The Journal of Biological Chemistry. 268 (16): 11758–65. PMID 8505303. 
  2. ^ Carter JR, Franden MA, Aebersold R, McHenry CS (1992). "Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme" (PDF). Journal of Bacteriology. 174 (21): 7013–25. PMC 207382Freely accessible. PMID 1400251.