Glucose-fructose oxidoreductase

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glucose-fructose oxidoreductase
EC no.
CAS no.94949-35-6
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glucose-fructose oxidoreductase (EC is an enzyme that catalyzes the chemical reaction

D-glucose + D-fructose D-gluconolactone + D-glucitol

Thus, the two substrates of this enzyme are D-glucose and D-fructose, whereas its two products are D-gluconolactone and D-glucitol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is D-glucose:D-fructose oxidoreductase.

Structural studies[edit]

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1H6A, 1H6B, 1H6C, 1H6D, 1OFG, 1RYD, and 1RYE.


  • Zachariou M; Scopes RK (1986). "Glucose-fructose oxidoreductase: a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production". J. Bacteriol. 167 (3): 863–869. doi:10.1128/JB.167.3.863-869.1986. PMC 215953. PMID 3745122.
  • Hardman MJ, Scopes RK (1988). "The kinetics of glucose-fructose oxidoreductase from Zymomonas mobilis". Eur. J. Biochem. 173 (1): 203–9. doi:10.1111/j.1432-1033.1988.tb13985.x. PMID 3356190.
  • Kanagasundaram V, Scopes RK (1992). "Cloning, sequence analysis, and expression of the structural gene encoding glucose-fructose oxidoreductase from Zymomonas mobilis". J. Bacteriol. 174 (5): 1439–47. doi:10.1128/jb.174.5.1439-1447.1992. PMC 206538. PMID 1537789.