Glucose 1-dehydrogenase

From Wikipedia, the free encyclopedia
glucose 1-dehydrogenase
Glucose dehydrogenase tetramer, Caenorhabditis Elegans
EC no.
CAS no.9028-53-9
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a glucose 1-dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

beta-D-glucose + NAD(P)+ D-glucono-1,5-lactone + NAD(P)H + H+

The 3 substrates of this enzyme are beta-D-glucose, NAD+, and NADP+, whereas its 4 products are D-glucono-1,5-lactone, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is beta-D-glucose:NAD(P)+ 1-oxidoreductase. Another name in common use is D-glucose dehydrogenase (NAD(P)+).

Structural studies[edit]

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1G6K, 1GCO, 1GEE, 1RWB, 1SPX, 2B5V, 2B5W, 2CD9, and 2CDA.


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