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Glycerol-3-phosphate 1-dehydrogenase (NADP+)

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glycerol-3-phosphate 1-dehydrogenase (NADP+)
Identifiers
EC no.1.1.1.177
CAS no.37213-46-0
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IntEnzIntEnz view
BRENDABRENDA entry
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MetaCycmetabolic pathway
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In enzymology, a glycerol-3-phosphate 1-dehydrogenase (NADP+) (EC 1.1.1.177) is an enzyme that catalyzes the chemical reaction

sn-glycerol 3-phosphate + NADP+ D-glyceraldehyde 3-phosphate + NADPH + H+

Thus, the two substrates of this enzyme are sn-glycerol 3-phosphate and NADP+, whereas its 3 products are D-glyceraldehyde 3-phosphate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sn-glycerol-3-phosphate:NADP+ 1-oxidoreductase. Other names in common use include glycerol phosphate (nicotinamide adenine dinucleotide phosphate), dehydrogenase, L-glycerol 3-phosphate:NADP+ oxidoreductase, glycerin-3-phosphate dehydrogenase, NADPH-dependent glycerin-3-phosphate dehydrogenase, and glycerol-3-phosphate 1-dehydrogenase (NADP+).

References

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  • Glushankov PE, Epifanova VE, Kolotilova AI (1976). "Pentose phosphate pathway of carbohydrate metabolism and NADP-dependent glycerol 3-phosphate dehydrogenase activity in some white rat tissues". Biokhimiya. 41: 1788–1790.
  • Wood T (1974). "Catalysis of pentose phosphate pathway reactions by cytoplasmic fractions from muscle, uterus and liver of the rat, and the presence of a reduced nicotinamide-adenine dinucleotide phosphate-triose phosphate oxidoreductase in rat muscle". Biochem. J. 138 (1): 71–6. PMC 1166176. PMID 4152128.