Artime had a remarkably successful career in club football, he was top scorer four times in the Argentine league, three times in the Uruguayan league and once in the Copa Libertadores. he won one Argentine league title, three Uruguayan league titles and the Copa Libertadores in 1971.
In 1969 he moved to Brazil to play for Palmeiras, but he didn't stay long, and soon left to join Nacional of Uruguay. His first spell at Nacional was the most productive of his career; he won 3 Urugauyan league titles in a row, topscoring in each tournament, and in 1971 he helped the team to win the Copa Libertadores.
In 1972 he tried his luck in Brazil for a second time, but returned to Nacional in Uruguay after only one season at Fluminense. His second spell at Nacional was overshadowed by the successes of eternal rivals Peñarol. Artime retired from football in 1974.