MN1 (gene)

MN1
Identifiers
Aliases	MN1, MGCR, MGCR1, MGCR1-PEN, dJ353E16.2, meningioma (disrupted in balanced translocation) 1, MN1 proto-oncogene, transcriptional regulator, CEBALID
External IDs	OMIM: 156100 MGI: 1261813 HomoloGene: 37620 GeneCards: MN1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	27,801,756 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	111,604,899 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; vastus lateralis muscle; ; triceps brachii muscle; ; deltoid muscle; ; body of tongue; ; gastrocnemius muscle; ; saphenous vein; ; thoracic diaphragm; ; external globus pallidus; ; tibialis anterior muscle;
	Top expressed in
	ganglionic eminence; ; medial ganglionic eminence; ; ankle; ; extraocular muscle; ; digastric muscle; ; otolith organ; ; utricle; ; external carotid artery; ; tibialis anterior muscle; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	cellular component;
Biological process	multicellular organism development; intramembranous ossification; regulation of transcription, DNA-templated; transcription, DNA-templated; biological process;
	Sources:Amigo / QuickGO
Orthologs
	4330
	433938
	ENSG00000169184
	ENSMUSG00000070576
	Q10571
	D3YWE6
	NM_002430
	NM_001081235
	NP_002421
	NP_001074704
	Wikidata
View/Edit Human	View/Edit Mouse

MN1 is a gene found on human chromosome 22, with gene map locus 22q12.3-qter.^[5] Its official full name is meningioma (disrupted in balanced translocation) 1 because it is disrupted by a balanced translocation (4;22) in a meningioma.

Function

MN1 is a transcription coregulator that enhances or represses RAR/RXR-mediated gene transcription through interaction with RAC3 and p300.^[6] MN1 also acts as a coactivator of the vitamin D receptor.^[7]

Clinical significance

Its inactivation may be part of the cause of certain meningiomas.^[5] A potential link to leukemia^[8] including acute myeloid leukemia^[9] has also been described.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169184 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070576 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, Bootsma D, de Jong PJ, Menon AG, Kley NA (April 1995). "Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma". Oncogene. 10 (8): 1521–8. PMID 7731706.
^ van Wely KH, Molijn AC, Buijs A, Meester-Smoor MA, Aarnoudse AJ, Hellemons A, den Besten P, Grosveld GC, Zwarthoff EC (February 2003). "The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription". Oncogene. 22 (5): 699–709. doi:10.1038/sj.onc.1206124. PMID 12569362.
^ Sutton AL, Zhang X, Ellison TI, Macdonald PN (September 2005). "The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation". Mol. Endocrinol. 19 (9): 2234–44. doi:10.1210/me.2005-0081. PMID 15890672.
^ Buijs A, Sherr S, van Baal S, et al. (April 1995). "Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8): 1511–9. PMID 7731705.
^ Grosveld GC (2007). "MN1, a novel player in human AML". Blood Cells Mol. Dis. 39 (3): 336–9. doi:10.1016/j.bcmd.2007.06.009. PMC 2387274. PMID 17698380.

Kawagoe H, Grosveld GC (2005). "MN1-TEL myeloid oncoprotein expressed in multipotent progenitors perturbs both myeloid and lymphoid growth and causes T-lymphoid tumors in mice". Blood. 106 (13): 4278–86. doi:10.1182/blood-2005-04-1674. PMC 1895241. PMID 16081688.
Schroeder T, Czibere A, Zohren F, et al. (2009). "Meningioma 1 gene is differentially expressed in CD34 positive cells from bone marrow of patients with myelodysplastic syndromes with the highest expression in refractory anemia with excess of blasts and secondary acute myeloid leukemia". Leuk. Lymphoma. 50 (6): 1043–6. doi:10.1080/10428190902913591. PMID 19391034.
Meester-Smoor MA, Janssen MJ, Grosveld GC, et al. (2008). "MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression". Carcinogenesis. 29 (10): 2025–34. doi:10.1093/carcin/bgn168. PMC 3202306. PMID 18632758.
Carella C, Bonten J, Sirma S, et al. (2007). "MN1 overexpression is an important step in the development of inv(16) AML". Leukemia. 21 (8): 1679–90. doi:10.1038/sj.leu.2404778. PMID 17525718.
Heuser M, Argiropoulos B, Kuchenbauer F, et al. (2007). "MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML". Blood. 110 (5): 1639–47. doi:10.1182/blood-2007-03-080523. PMID 17494859.
Langer C, Marcucci G, Holland KB, et al. (2009). "Prognostic importance of MN1 transcript levels, and biologic insights from MN1-associated gene and microRNA expression signatures in cytogenetically normal acute myeloid leukemia: a cancer and leukemia group B study". J. Clin. Oncol. 27 (19): 3198–204. doi:10.1200/JCO.2008.20.6110. PMC 2716941. PMID 19451432.
Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Kawagoe H, Grosveld GC (2005). "Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9". Blood. 106 (13): 4269–77. doi:10.1182/blood-2005-04-1679. PMC 1895240. PMID 16105979.
Kandilci A, Grosveld GC (2009). "Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation". Blood. 114 (8): 1596–606. doi:10.1182/blood-2009-02-205443. PMC 2731639. PMID 19561324.
Trynka G, Zhernakova A, Romanos J, et al. (2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061.
Gastier JM, Brody T, Pulido JC, et al. (1996). "Development of a screening set for new (CAG/CTG)n dynamic mutations". Genomics. 32 (1): 75–85. doi:10.1006/geno.1996.0078. PMID 8786123.
Collins JE, Wright CL, Edwards CA, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Meester-Smoor MA, Molijn AC, Zhao Y, et al. (2007). "The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence". J. Mol. Endocrinol. 38 (1–2): 113–25. doi:10.1677/jme.1.02110. PMID 17242174.
Buijs A, Sherr S, van Baal S, et al. (1995). "Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8): 1511–9. PMID 7731705.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169184 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070576 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7731706-5] Lekanne Deprez RH, Riegman PH, Groen NA, Warringa UL, van Biezen NA, Molijn AC, Bootsma D, de Jong PJ, Menon AG, Kley NA (April 1995). "Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma". Oncogene. 10 (8): 1521–8. PMID 7731706.

[pmid12569362-6] van Wely KH, Molijn AC, Buijs A, Meester-Smoor MA, Aarnoudse AJ, Hellemons A, den Besten P, Grosveld GC, Zwarthoff EC (February 2003). "The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription". Oncogene. 22 (5): 699–709. doi:10.1038/sj.onc.1206124. PMID 12569362.

[pmid15890672-7] Sutton AL, Zhang X, Ellison TI, Macdonald PN (September 2005). "The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation". Mol. Endocrinol. 19 (9): 2234–44. doi:10.1210/me.2005-0081. PMID 15890672.

[pmid7731705-8] Buijs A, Sherr S, van Baal S, et al. (April 1995). "Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8): 1511–9. PMID 7731705.

[pmid17698380-9] Grosveld GC (2007). "MN1, a novel player in human AML". Blood Cells Mol. Dis. 39 (3): 336–9. doi:10.1016/j.bcmd.2007.06.009. PMC 2387274. PMID 17698380.

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[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

v t e Transcription coregulators
Coactivators	ARA (54, 55, 70) BCAS3 CARM1 p300-CBP (EP300, CREBBP) CRTC (1, 2, 3) DRIP/TRAP (MED1 Drip205/Trap220) MN1 PCAF PNRC (1, 2) PPARGC (1A, 1B) TGFB1I1 NCOA1 (SRC-1) NCOA2 (GRIP1/SRC-2/TIF2) NCOA3 (AIB/SRC-3/TRAM-1) NCOA4 (ARA70) NCOA5 (CIA) NCOA6 (RAP250) NCOA7 (ERAP140)
Corepressors	CTBP (1, 2) Hairless homolog LCOR NRIP1 (RIP140) PELP-1 RCOR1 Rb SIN3A SIN3B Tripartite motif family TRIM (24, 28, 33) NCOR1 NCOR2 (SMRT)
ATP-dependent remodeling factors	Chromatin Structure Remodeling (RSC) Complex SWI/SNF

Function

Clinical significance

References

Further reading