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Methylecgonone reductase

From Wikipedia, the free encyclopedia
Methylecgonone reductase
Identifiers
EC no.1.1.1.334
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Methylecgonone reductase (EC 1.1.1.334, MecgoR (gene name)) is an enzyme with systematic name ecgonine methyl ester:NADP+ oxidoreductase.[1] This enzyme catalyses the following chemical reaction

ecgonine methyl ester + NADP+ ecgonone methyl ester + NADPH + H+

The enzyme from the plant Erythroxylum coca participates in the biosynthesis of cocaine.

References

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  1. ^ Jirschitzka J, Schmidt GW, Reichelt M, Schneider B, Gershenzon J, D'Auria JC (June 2012). "Plant tropane alkaloid biosynthesis evolved independently in the Solanaceae and Erythroxylaceae". Proceedings of the National Academy of Sciences of the United States of America. 109 (26): 10304–9. Bibcode:2012PNAS..10910304J. doi:10.1073/pnas.1200473109. PMC 3387132. PMID 22665766.
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