NLRP2

NLRP2
Identifiers
Aliases	NLRP2, CLR19.9, NALP2, NBS1, PAN1, PYPAF2, NLR family, pyrin domain containing 2, NLR family pyrin domain containing 2
External IDs	OMIM: 609364; MGI: 3041206; HomoloGene: 56789; GeneCards: NLRP2; OMA:NLRP2 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	55,001,142 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	5,354,034 bp
RNA expression pattern
	Top expressed in
	gonad; ; placenta; ; testicle; ; granulocyte; ; left testis; ; right testis; ; ganglionic eminence; ; mucosa of transverse colon; ; lymph node; ; blood;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; morula; ; ovarian follicle; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	Pyrin domain binding; nucleotide binding; protein binding; ATP binding;
Cellular component	cytoplasm; Golgi apparatus; intracellular membrane-bounded organelle; cytosol;
Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; inflammatory response; innate immune response; immune system process; apoptotic process; negative regulation of NF-kappaB transcription factor activity;
	Sources:Amigo / QuickGO
Orthologs
	55655
	232827
ENSG00000278789; ENSG00000275796; ENSG00000277060; ENSG00000275843; ENSG00000275399;
	ENSG00000022556; ENSG00000275082; ENSG00000278682; ENSG00000274638; ENSG00000273992
	ENSMUSG00000035177
	Q9NX02
	n/a
	NM_017852; NM_001174081; NM_001174082; NM_001174083; NM_001348003
	NM_177690
	NP_001167552; NP_001167553; NP_001167554; NP_060322; NP_001334932
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000275796, ENSG00000277060, ENSG00000275843, ENSG00000275399, ENSG00000022556, ENSG00000275082, ENSG00000278682, ENSG00000274638, ENSG00000273992 GRCh38: Ensembl release 89: ENSG00000278789, ENSG00000275796, ENSG00000277060, ENSG00000275843, ENSG00000275399, ENSG00000022556, ENSG00000275082, ENSG00000278682, ENSG00000274638, ENSG00000273992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035177 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
^ Bertin J, DiStefano PS (Mar 2001). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell Death Differ. 7 (12): 1273–4. doi:10.1038/sj.cdd.4400774. PMID 11270363.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

v t e NOD-like receptor family
CARD domain containing	NOD1/NLRC1 NOD2/NLRC2 NLRC3 NLRC4 NLRC5
Pyrin domain containing	NLRP1 NLRP2 NLRP3 NLRP4 NLRP5 NLRP6 NLRP7 NLRP8 NLRP9 NLRP10 NLRP11 NLRP12 NLRP13 NLRP14
Apoptosis inhibitory protein	NAIP
Family member X1	NLRX1

References

Further reading