Jump to content

NLRP5

From Wikipedia, the free encyclopedia
(Redirected from NLRP5 (gene))
NLRP5
Identifiers
AliasesNLRP5, CLR19.8, MATER, NALP5, PAN11, PYPAF8, NLR family, pyrin domain containing 5, NLR family pyrin domain containing 5
External IDsOMIM: 609658; MGI: 1345193; HomoloGene: 65105; GeneCards: NLRP5; OMA:NLRP5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_153447

NM_001039143
NM_011860
NM_001305857

RefSeq (protein)

NP_703148

NP_001034232
NP_001292786
NP_035990

Location (UCSC)Chr 19: 56 – 56.06 MbChr 7: 23.09 – 23.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NLRP5, short for NOD-like receptor family pyrin domain containing 5, is an intracellular protein that plays a role in early embryogenesis.[5][6] NLRP5 is also known as NACHT, LRR and PYD domains-containing protein 5 (NALP5), Mater protein homolog (MATER), PYPAF8, PAN11, and CLR19.8, and is one of 14 pyrin domain containing members of the NOD-like receptor family of cytoplasmic receptors known to mammals.

In humans, the NLRP5 protein is encoded by the NLRP5 gene.[7][8][9]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171487Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015721Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wu X (February 2009). "Maternal depletion of NLRP5 blocks early embryogenesis in rhesus macaque monkeys (Macaca mulatta)". Hum. Reprod. 24 (2): 415–24. doi:10.1093/humrep/den403. PMID 19054779.
  6. ^ Pisani LF, Ramelli P, Lazzari B, Braglia S, Ceciliani F, Mariani P (February 2010). "Characterization of maternal antigen that embryos require (MATER/NLRP5) gene and protein in pig somatic tissues and germ cells". J. Reprod. Dev. 56 (1): 41–8. doi:10.1262/jrd.09-098a. PMID 19815987.
  7. ^ "Entrez Gene: NLR family".
  8. ^ Tong ZB, Bondy CA, Zhou J, Nelson LM (April 2002). "A human homologue of mouse Mater, a maternal effect gene essential for early embryonic development". Hum. Reprod. 17 (4): 903–11. doi:10.1093/humrep/17.4.903. PMID 11925379.
  9. ^ Tschopp J, Martinon F, Burns K (February 2003). "NALPs: a novel protein family involved in inflammation". Nat. Rev. Mol. Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287. S2CID 31417018.

Further reading

[edit]