Pyrantel

Pyrantel
Names
	IUPAC name 1-Methyl-2-[(E)-2-(2-thienyl)vinyl]-5,6-dihydro-4H-pyrimidine
Identifiers
CAS Number	15686-83-6 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:8654 ;
ChEMBL	ChEMBL1626223 ;
ECHA InfoCard	100.036.143
KEGG	D08451 ;
MeSH	Pyrantel
PubChem CID	708857;
UNII	4QIH0N49E7 ;
CompTox Dashboard (EPA)	DTXSID5023538 ;
	SMILES CN1CCCN=C1C=CC2=CC=CS2;
Properties
Chemical formula	C11H14N2S
Molar mass	206.31 g/mol
Pharmacology
ATC code	P02CC01 (WHO) QP52AF02 (WHO)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Pyrantel is an antinematodal thiophene. It is often prescribed by veterinarians to treat and prevent the occurrence of intestinal parasites in small animal pets.

It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.^[1]

Mechanism of action

Pyrantel is a nicotinic receptor agonist.^[2]^[3] Like levamisole and the related pyrimidine morantel, it can elicit spastic muscle paralysis in parasitic worms due to prolonged activation of the excitatory nicotinic acetylcholine (nACh) receptors on body wall muscle. This has been studied in body wall muscle preparation of the parasitic nematode Ascaris.^[4]

References

^ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
^ Aceves, J., Erlij, D., and Martinez-Maranon, R. (1970). The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle. Br. J. Pharmacol. 38, 602–607.
^ Aubry, M.L., Cowell, P., Davey, M.J., and Shevde, S. (1970). Aspects of the pharmacology of a new anthelmintic: pyrantel. Br. J. Pharmacol. 38, 332–344.
^ Martin, R.J., Verma, S., Levandoski, M., Clark, C.L., Qian, H., Stewart, M., and Robertson, A.P. (2005). Drug resistance and neurotransmitter receptors of nematodes: recent studies on the mode of action of levamisole. Parasitology 131, S71–S84.

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[1] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[2] Aceves, J., Erlij, D., and Martinez-Maranon, R. (1970). The mechanism of the paralysing action of tetramisole on Ascaris somatic muscle. Br. J. Pharmacol. 38, 602–607.

[3] Aubry, M.L., Cowell, P., Davey, M.J., and Shevde, S. (1970). Aspects of the pharmacology of a new anthelmintic: pyrantel. Br. J. Pharmacol. 38, 332–344.

[4] Martin, R.J., Verma, S., Levandoski, M., Clark, C.L., Qian, H., Stewart, M., and Robertson, A.P. (2005). Drug resistance and neurotransmitter receptors of nematodes: recent studies on the mode of action of levamisole. Parasitology 131, S71–S84.

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Mechanism of action

See also

References