Ribitol 2-dehydrogenase

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ribitol 2-dehydrogenase
EC no.
CAS no.9014-23-7
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a ribitol 2-dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

ribitol + NAD+ D-ribulose + NADH + H+

Thus, the two substrates of this enzyme are ribitol and NAD+, whereas its 3 products are D-ribulose, NADH, and H+.

This enzyme participates in pentose and glucuronate interconversions.


This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ribitol:NAD+ 2-oxidoreductase. Other names in common use include adonitol dehydrogenase, ribitol dehydrogenase A (wild type), ribitol dehydrogenase B (mutant enzyme with different properties), and ribitol dehydrogenase D (mutant enzyme with different properties).


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  • Nordlie RC, Fromm HJ (Oct 1959). "Ribitol dehydrogenase. II. Studies on the reaction mechanism". The Journal of Biological Chemistry. 234: 2523–31. PMID 14427582.
  • Wood WA, McDonough MJ, Jacobs LB (Aug 1961). "Ribitol and D-arabitol utilization by Aerobacter aerogenes". The Journal of Biological Chemistry. 236: 2190–5. PMID 13786517.