Ribose 1-dehydrogenase (NADP+)

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ribose 1-dehydrogenase (NADP+)
EC number
CAS number 37250-46-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a ribose 1-dehydrogenase (NADP+) (EC is an enzyme that catalyzes the chemical reaction

D-ribose + NADP+ + H2O D-ribonate + NADPH + H+

The three substrates of this enzyme are D-ribose, NADP+, and H2O, whereas its 3 products are D-ribonate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-ribose:NADP+ 1-oxidoreductase. Other names in common use include D-ribose dehydrogenase (NADP+), NADP+-pentose-dehydrogenase, and ribose 1-dehydrogenase (NADP+).


  • Scher BM, Horecker BL (1966). "Pentose metabolism in Candida. 3. The triphosphopyridine nucleotide-specific polyol dehydrogenase of Candida utilis". Arch. Biochem. Biophys. 116 (1): 117–28. doi:10.1016/0003-9861(66)90020-8. PMID 4381350. 
  • Schiwara HW, Domschke W, Domagk GF (1968). "[Sugar dehydrogenases in mammalian liver. I. Differentiation of various sugar dehydrogenases from pig liver by disc electrophoresis and ion exchange chromatography]". Hoppe-Seyler's Z. Physiol. Chem. 349 (11): 1575–81. doi:10.1515/bchm2.1968.349.2.1575. PMID 4393642.