SOCS5

SOCS5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2N34
Identifiers
Aliases	SOCS5, CIS6, CISH6, Cish5, SOCS-5, suppressor of cytokine signaling 5
External IDs	OMIM: 607094; MGI: 2385459; HomoloGene: 10495; GeneCards: SOCS5; OMA:SOCS5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	46,780,245 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	87,445,267 bp
RNA expression pattern
	Top expressed in
	sperm; ; buccal mucosa cell; ; endothelial cell; ; germinal epithelium; ; lactiferous duct; ; parietal pleura; ; saphenous vein; ; cerebellar vermis; ; stromal cell of endometrium; ; Epithelium of choroid plexus;
	Top expressed in
	substantia nigra; ; ventromedial nucleus; ; anterior amygdaloid area; ; nucleus accumbens; ; lateral septal nucleus; ; olfactory tubercle; ; mammillary body; ; globus pallidus; ; lateral hypothalamus; ; subiculum;
	More reference expression data
	n/a
Gene ontology
Molecular function	epidermal growth factor receptor binding; protein kinase inhibitor activity; receptor tyrosine kinase binding; protein binding; 1-phosphatidylinositol-3-kinase regulator activity;
Cellular component	cytoplasm; cytosol; phosphatidylinositol 3-kinase complex;
Biological process	receptor signaling pathway via JAK-STAT; intracellular signal transduction; epidermal growth factor receptor signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; cell growth; protein ubiquitination; regulation of growth; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of T-helper 2 cell differentiation; positive regulation of T-helper 1 cell differentiation; negative regulation of signal transduction; negative regulation of interleukin-6 production; negative regulation of inflammatory response; cellular response to low-density lipoprotein particle stimulus; negative regulation of monocyte chemotactic protein-1 production; vascular endothelial cell response to fluid shear stress; post-translational protein modification; cytokine-mediated signaling pathway; regulation of phosphatidylinositol 3-kinase activity; phosphatidylinositol phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	9655
	56468
	ENSG00000171150
	ENSMUSG00000037104
	O75159
	O54928
	NM_144949; NM_014011
	NM_019654
	NP_054730; NP_659198
	NP_062628
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 5 is a protein that in humans is encoded by the SOCS5 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037104 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

References

Further reading