Secoisolariciresinol dehydrogenase
| Secoisolariciresinol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.331 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Secoisolariciresinol dehydrogenase (EC 1.1.1.331) is an enzyme with systematic name (-)-secoisolariciresinol:NAD+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- (-)-secoisolariciresinol + 2 NAD+ (-)-matairesinol + 2 NADH + 2 H+
This enzyme is isolated from the plants Forsythia intermedia and Podophyllum peltatum.
References
- ^ Xia, Z.Q., Costa, M.A., Pelissier, H.C., Davin, L.B. and Lewis, N.G. (2001). "Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection". J. Biol. Chem. 276 (16): 12614–12623. doi:10.1074/jbc.M008622200. PMID 11278426.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Youn, B., Moinuddin, S.G., Davin, L.B., Lewis, N.G. and Kang, C. (2005). "Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans". J. Biol. Chem. 280 (13): 12917–12926. doi:10.1074/jbc.M413266200. PMID 15653677.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Moinuddin, S.G., Youn, B., Bedgar, D.L., Costa, M.A., Helms, G.L., Kang, C., Davin, L.B. and Lewis, N.G. (2006). "Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum". Org. Biomol. Chem. 4 (5): 808–816. doi:10.1039/b516563f. PMID 16493463.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
External links
- Secoisolariciresinol+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)