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Tetraspanin 2
Symbols TSPAN2 ; NET3; TSN2; TSPAN-2
External IDs OMIM613133 MGI1917997 HomoloGene21169 GeneCards: TSPAN2 Gene
RNA expression pattern
PBB GE TSPAN2 214606 at tn.png
More reference expression data
Species Human Mouse
Entrez 10100 70747
Ensembl ENSG00000134198 ENSMUSG00000027858
UniProt O60636 Q922J6
RefSeq (mRNA) NM_001308315 NM_001243132
RefSeq (protein) NP_001295244 NP_001230061
Location (UCSC) Chr 1:
115.05 – 115.09 Mb
Chr 3:
102.73 – 102.8 Mb
PubMed search [1] [2]

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.[1][2][3]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.[3]


  1. ^ Todd SC, Doctor VS, Levy S (Sep 1998). "Sequences and expression of six new members of the tetraspanin/TM4SF family". Biochim Biophys Acta 1399 (1): 101–4. doi:10.1016/s0167-4781(98)00087-6. PMID 9714763. 
  2. ^ Berditchevski F (Dec 2001). "Complexes of tetraspanins with integrins: more than meets the eye". J Cell Sci 114 (Pt 23): 4143–51. PMID 11739647. 
  3. ^ a b "Entrez Gene: TSPAN2 tetraspanin 2". 

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