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Tetraspanin 8
Symbols TSPAN8 ; CO-029; TM4SF3
External IDs OMIM600769 MGI2384918 HomoloGene20968 GeneCards: TSPAN8 Gene
RNA expression pattern
PBB GE TSPAN8 203824 at tn.png
More reference expression data
Species Human Mouse
Entrez 7103 216350
Ensembl ENSG00000127324 ENSMUSG00000034127
UniProt P19075 Q8R3G9
RefSeq (mRNA) NM_004616 NM_001168679
RefSeq (protein) NP_004607 NP_001162150
Location (UCSC) Chr 12:
71.13 – 71.44 Mb
Chr 10:
115.82 – 115.85 Mb
PubMed search [1] [2]

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.[2]


  1. ^ Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (Oct 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proc Natl Acad Sci U S A 87 (17): 6833–7. doi:10.1073/pnas.87.17.6833. PMC 54632. PMID 2395876. 
  2. ^ a b "Entrez Gene: TSPAN8 tetraspanin 8". 

Further reading[edit]