TSPAN8

From Wikipedia, the free encyclopedia
Jump to: navigation, search
TSPAN8
Identifiers
Aliases TSPAN8, CO-029, TM4SF3, tetraspanin 8
External IDs MGI: 2384918 HomoloGene: 20968 GeneCards: TSPAN8
RNA expression pattern
PBB GE TSPAN8 203824 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004616

NM_001168679
NM_001168680
NM_146010

RefSeq (protein)

NP_004607

NP_001162150
NP_001162151
NP_666122

Location (UCSC) Chr 12: 71.13 – 71.44 Mb Chr 10: 115.82 – 115.85 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.[3][4]

Function[edit]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.[4]

Clinical significance[edit]

Overall survival of breast cancer patients was effectively predicted by TSPAN8.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. PMC 54632Freely accessible. PMID 2395876. doi:10.1073/pnas.87.17.6833. 
  4. ^ a b "Entrez Gene: TSPAN8 tetraspanin 8". 
  5. ^ Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples". International Journal of Cancer. 131 (1): 95–105. PMID 21858809. doi:10.1002/ijc.26364. 

Further reading[edit]