TSPAN4

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TSPAN4
Identifiers
Aliases TSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDs MGI: 1928097 HomoloGene: 2453 GeneCards: TSPAN4
RNA expression pattern
PBB GE TSPAN4 209263 x at fs.png

PBB GE TSPAN4 209264 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001252588
NM_053082

RefSeq (protein)

NP_001239517
NP_444312

Location (UCSC) Chr 11: 0.84 – 0.87 Mb Chr 7: 141.48 – 141.49 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.[3][4]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.[4]

Interactions[edit]

TSPAN4 has been shown to interact with CD9,[3] ITGA6,[3] CD29,[3] CD49c[3] and CD81.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c d e f Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. PMID 9360996. doi:10.1074/jbc.272.46.29181. 
  4. ^ a b "Entrez Gene: TSPAN4 tetraspanin 4". 

Further reading[edit]