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AliasesTSPAN4, NAG-2, NAG2, TETRASPAN, TM4SF7, TSPAN-4, tetraspanin 4
External IDsOMIM: 602644 MGI: 1928097 HomoloGene: 2453 GeneCards: TSPAN4
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for TSPAN4
Genomic location for TSPAN4
Band11p15.5Start842,808 bp[1]
End867,116 bp[1]
RNA expression pattern
PBB GE TSPAN4 209263 x at fs.png

PBB GE TSPAN4 209264 s at fs.png
More reference expression data
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 11: 0.84 – 0.87 MbChr 7: 141.48 – 141.49 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.[5][6]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.[6]


TSPAN4 has been shown to interact with CD9,[5] ITGA6,[5] CD29,[5] CD49c[5] and CD81.[5]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000214063 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025511 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b c d e f Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
  6. ^ a b "Entrez Gene: TSPAN4 tetraspanin 4".

Further reading[edit]