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Tetraspanin 4
External IDs OMIM602644 MGI1928097 HomoloGene2453 GeneCards: TSPAN4 Gene
RNA expression pattern
PBB GE TSPAN4 209264 s at tn.png
PBB GE TSPAN4 209263 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7106 64540
Ensembl ENSG00000214063 ENSMUSG00000025511
UniProt O14817 Q9DCK3
RefSeq (mRNA) NM_001025234 NM_001252588
RefSeq (protein) NP_001020405 NP_001239517
Location (UCSC) Chr 11:
0.84 – 0.87 Mb
Chr 7:
141.48 – 141.49 Mb
PubMed search [1] [2]

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]


TSPAN4 has been shown to interact with CD9,[1] ITGA6,[1] CD29,[1] CD49c[1] and CD81.[1]


  1. ^ a b c d e f Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (Dec 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J Biol Chem 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996. 
  2. ^ a b "Entrez Gene: TSPAN4 tetraspanin 4". 

Further reading[edit]