CD37

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CD37
Identifiers
Aliases CD37, GP52-40, TSPAN26, CD37 molecule
External IDs OMIM: 151523 MGI: 88330 HomoloGene: 20422 GeneCards: 951
RNA expression pattern
PBB GE CD37 204192 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001040031
NM_001774

NM_007645
NM_001290802
NM_001290804

RefSeq (protein)

NP_001035120.1
NP_001765.1

NP_031671.1

Location (UCSC) Chr 19: 49.34 – 49.34 Mb Chr 7: 45.23 – 45.24 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[1][2]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms.[2]

See also[edit]

References[edit]

  1. ^ Virtaneva KI, Angelisova P, Baumruker T, Horejsi V, Nevanlinna H, Schroder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics 37 (6): 461–465. doi:10.1007/BF00222471. PMID 8436422. 
  2. ^ a b "Entrez Gene: CD37 CD37 molecule". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.