adipocyte protein 2

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Fatty acid-binding protein, adipocyte
2HNX.png
Crystallographic structure adipocyte lipid-binding protein (PDB 2hnx) with palmitic acid (white sticks)[1]
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FABP4 ;A-FABP, AFABP
External IDs OMIM600434 HomoloGene36067 ChEMBL: 2083 GeneCards: FABP4 Gene
Orthologs
Species Human Mouse
Entrez 2167 11770
Ensembl n/a n/a
UniProt P15090 P04117
RefSeq (mRNA) NM_001442 NM_024406
RefSeq (protein) NP_001433 NP_077717
Location (UCSC) n/a n/a
PubMed search [1] [2]

aP2 (adipocyte Protein 2)[2] is a carrier protein for fatty acids that is primarily expressed in adipocytes and macrophages. aP2 is also called fatty acid binding protein 4 (FABP4). Blocking this protein either through genetic engineering or drugs[3][4] has the possibility of treating heart disease,[5] diabetes,[6] asthma,[7] obesity,[8] and fatty liver disease.[9]

See also[edit]

References[edit]

  1. ^ Marr, E.; Tardie, M.; Carty, M.; Brown Phillips, T.; Wang, I. K.; Soeller, W.; Qiu, X.; Karam, G. (2006). "Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)". Acta Crystallographica Section F Structural Biology and Crystallization Communications 62 (11): 1058–1060. doi:10.1107/S1744309106038656. PMC 2225221. PMID 17077479.  edit
  2. ^ Baxa CA, Sha RS, Buelt MK, Smith AJ, Matarese V, Chinander LL, Boundy KL, Bernlohr DA (1989). "Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA". Biochemistry 28 (22): 8683–90. doi:10.1021/bi00448a003. PMID 2481498. 
  3. ^ Forbes health article July 14, 2006
  4. ^ Medicinenet.com
  5. ^ Makowski L, Boord JB, Maeda K, Babaev VR, Uysal KT, Morgan MA, Parker RA, Suttles J, Fazio S, Hotamisligil GS, Linton MF (2001). "Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis". Nat. Med. 7 (6): 699–705. doi:10.1038/89076. PMID 11385507. 
  6. ^ Furuhashi M, Tuncman G, Görgün CZ, Makowski L, Atsumi G, Vaillancourt E, Kono K, Babaev VR, Fazio S, Linton MF, Sulsky R, Robl JA, Parker RA, Hotamisligil GS (2007). "Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2". Nature 447 (7147): 959–65. doi:10.1038/nature05844. PMID 17554340. 
  7. ^ Shum BO, Mackay CR, Gorgun CZ, Frost MJ, Kumar RK, Hotamisligil GS, Rolph MS (2006). "The adipocyte fatty acid-binding protein aP2 is required in allergic airway inflammation". J. Clin. Invest. 116 (8): 2183–2192. doi:10.1172/JCI24767. PMC 1501108. PMID 16841093. 
  8. ^ Maeda K, Cao H, Kono K, Gorgun CZ, Furuhashi M, Uysal KT, Cao Q, Atsumi G, Malone H, Krishnan B, Minokoshi Y, Kahn BB, Parker RA, Hotamisligil GS (2005). "Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes". Cell Metab. 1 (2): 107–19. doi:10.1016/j.cmet.2004.12.008. PMID 16054052. 
  9. ^ Makowski L, Hotamisligil GS (2005). "The role of fatty acid binding proteins in metabolic syndrome and atherosclerosis". Curr. Opin. Lipidol. 16 (5): 543–8. doi:10.1097/01.mol.0000180166.08196.07. PMID 16148539. 

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