FABP7

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Fatty acid binding protein 7, brain
Protein FABP7 PDB 1fdq.png
PDB rendering based on 1fdq.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FABP7 ; B-FABP; BLBP; FABPB; MRG
External IDs OMIM602965 MGI101916 HomoloGene37880 GeneCards: FABP7 Gene
RNA expression pattern
PBB GE FABP7 205030 at tn.png
PBB GE FABP7 205029 s at tn.png
PBB GE FABP7 216192 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2173 12140
Ensembl ENSG00000164434 ENSMUSG00000019874
UniProt O15540 P51880
RefSeq (mRNA) NM_001446 NM_021272
RefSeq (protein) NP_001437 NP_067247
Location (UCSC) Chr 6:
123.1 – 123.11 Mb
Chr 10:
57.78 – 57.79 Mb
PubMed search [1] [2]

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.[1] The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.[1]

FABP7 is expressed, during development, in radial glia by the activation of Notch receptors.[2] Reelin was shown to induce FABP7 expression in neural progenitor cells via Notch-1 activation.[3]

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.[4]

Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.

Role in pathology[edit]

FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.[5]

As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,[6] with one, that tested for only one SNP, showing negative[7] and another, with seven SNPs,[8] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.


References[edit]

  1. ^ a b "Entrez Gene: FABP7 fatty acid binding protein 7, brain". 
  2. ^ Anthony TE, Mason HA, Gridley T, Fishell G, Heintz N (May 2005). "Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells". Genes Dev. 19 (9): 1028–33. doi:10.1101/gad.1302105. PMC 1091737. PMID 15879553. 
  3. ^ Keilani S, Sugaya K (July 2008). "Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1". BMC Dev. Biol. 8 (1): 69. doi:10.1186/1471-213X-8-69. PMC 2447831. PMID 18593473. 
  4. ^ Xu LZ, Sánchez R, Sali A, Heintz N (October 1996). "Ligand specificity of brain lipid-binding protein". J. Biol. Chem. 271 (40): 24711–9. doi:10.1074/jbc.271.40.24711. PMID 8798739. 
  5. ^ Lewis CM, Levinson DF, Wise LH, et al. (July 2003). "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia". Am. J. Hum. Genet. 73 (1): 34–48. doi:10.1086/376549. PMC 1180588. PMID 12802786. 
  6. ^ Gene Overview of All Published Schizophrenia-Association Studies for FABP7 - SZGene database at Schizophrenia Research Forum website.
  7. ^ Jungerius BJ, Hoogendoorn ML, Bakker SC, et al. (September 2007). "An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia". Mol. Psychiatry 13 (11): 1060–8. doi:10.1038/sj.mp.4002080. PMID 17893707. 
  8. ^ Watanabe A, Toyota T, Owada Y, et al. (November 2007). "Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype". PLoS Biol. 5 (11): e297. doi:10.1371/journal.pbio.0050297. PMC 2071943. PMID 18001149. 

Further reading[edit]

External links[edit]