Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene. The protein encoded by this gene is a brain fatty acid binding protein. Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.
According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.
Expression of Fabp7 protein in mouse brains at embryonic day 16 (left) and postnatal day 0 (right). At both stages, Fabp7 is strongly expressed in the ventricular zone and radial glia, where neurogenesis is prominent.
FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.
As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia, with one, that tested for only one SNP, showing negative and another, with seven SNPs, a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.
Shi YE, Ni J, Xiao G et al. (1997). "Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG.". Cancer Res.57 (15): 3084–91. PMID9242429.
Shimizu F, Watanabe TK, Shinomiya H et al. (1997). "Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP).". Biochim. Biophys. Acta1354 (1): 24–8. doi:10.1016/S0167-4781(97)00115-2. PMID9375786.
Godbout R, Bisgrove DA, Shkolny D, Day RS (1998). "Correlation of B-FABP and GFAP expression in malignant glioma.". Oncogene16 (15): 1955–62. doi:10.1038/sj.onc.1201740. PMID9591779.
Pu L, Igbavboa U, Wood WG et al. (1999). "Expression of fatty acid binding proteins is altered in aged mouse brain.". Mol. Cell. Biochem.198 (1-2): 69–78. doi:10.1023/A:1006946027619. PMID10497880.
Balendiran GK, Schnutgen F, Scapin G et al. (2000). "Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein.". J. Biol. Chem.275 (35): 27045–54. doi:10.1074/jbc.M003001200. PMID10854433.
Rademacher M, Zimmerman AW, Rüterjans H et al. (2003). "Solution structure of fatty acid-binding protein from human brain.". Mol. Cell. Biochem.239 (1-2): 61–8. doi:10.1023/A:1020566909213. PMID12479569.
Wang M, Liu YE, Goldberg ID, Shi YE (2004). "Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG.". J. Biol. Chem.278 (47): 47319–25. doi:10.1074/jbc.M308131200. PMID12975368.
Kaloshi G, Mokhtari K, Carpentier C et al. (2007). "FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status.". J. Neurooncol.84 (3): 245–8. doi:10.1007/s11060-007-9377-4. PMID17415524.