Calcium-binding proteins are proteins that participate in calcium cell signalling pathways by binding to Ca 2+.
The most ubiquitous Ca
2+-sensing protein, found in all eukaryotic organisms including yeasts, is calmodulin.
Intracellular storage and release of Ca
2+ from the sarcoplasmic reticulum is associated with the high-capacity, low-affinity calcium-binding protein calsequestrin. [1 ]
With their role in signal transduction, calcium-binding proteins contribute to all aspects of the cell's functioning, from homeostasis to
learning and memory. [2 ]
For example, the neuron-specific
calexcitin has been found to have an excitatory effect on neurons, and interacts with proteins that control the firing state of neurons, such as the voltage-dependent potassium channel. [3 ]
Compartmentalization of calcium binding proteins has been noted within cells, suggesting that these proteins perform distinct functions in localized calcium signaling.
It also indicates that in addition to freely diffusing through the cytoplasm to attain a homogeneous distribution, calcium binding proteins can bound to cellular structures through interactions that are likely important for their functions. [4 ] [4 ]
See also [ edit ]
References [ edit ]
^ Siegel, George (Ed.). Basic neurochemistry: molecular, cellular and medical aspects. Lippincott Williams and Wilkins / 1999 ISBN 0-397-51820-X
^ Prevagen Improves Memory. PREVAGEN®. Retrieved 2013-12-29.
^ Nelson T, Cavallaro S, Yi C, McPhie D, Schreurs B, Gusev P, Favit A, Zohar O, Kim J, Beushausen S, Ascoli G, Olds J, Neve R, Alkon D (1996). "Calexcitin: a signaling protein that binds calcium and GTP, inhibits potassium channels, and enhances membrane excitability". PNAS 93 (24): 13808–13. doi: 10.1073/pnas.93.24.13808. PMC 19433. PMID 8943017.
^ a b Mojumder DK, Wensel TG, Frishman LJ (Aug 2008). "Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina". Molecular Vision 14: 1600–1613. PMC 2528027.
3. Yáñez M, Gil-Longo J, Campos-Toimil M. Calcium binding proteins.
Adv Exp Med Biol. 2012;740:461-82. doi: 10.1007/978-94-007-2888-2_19.
External links [ edit ]
& calc. regulation
B trdu: iter ( nrpl/ grfl/ cytl/ horl), csrc ( lgic, enzr, gprc, igsr, intg, nrpr/ grfr/ cytr), itra ( adap, gbpr, mapk), calc, lipd; path ( hedp, wntp, tgfp+ mapp, notp, jakp, fsap, hipp, tlrp)