CCP110

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Centriolar coiled coil protein 110kDa
Identifiers
Symbols CCP110 ; CP110; Cep110
External IDs OMIM609544 MGI2141942 HomoloGene8810 GeneCards: CCP110 Gene
RNA expression pattern
PBB GE CP110 204662 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9738 101565
Ensembl ENSG00000103540 ENSMUSG00000033904
UniProt O43303 Q7TSH4
RefSeq (mRNA) NM_001199022 NM_182995
RefSeq (protein) NP_001185951 NP_892040
Location (UCSC) Chr 16:
19.54 – 19.56 Mb
Chr 7:
118.71 – 118.74 Mb
PubMed search [1] [2]

Centriolar coiled-coil protein of 110 kDa also known as centrosomal protein of 110 kDa or CP110 is a protein that in humans is encoded by the CCP110 gene. It is a cell cycle-dependent CDK substrate and regulates centrosome duplication.[1][2] CP110 suppresses a cilia assembly program.[3]

References[edit]

  1. ^ Chen Z, Indjeian VB, McManus M, Wang L, Dynlacht BD (September 2002). "CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells". Dev. Cell 3 (3): 339–50. doi:10.1016/S1534-5807(02)00258-7. PMID 12361598. 
  2. ^ Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD (March 2013). "USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110". Nature 495 (7440): 255–9. doi:10.1038/nature11941. PMID 23486064. 
  3. ^ Spektor A, Tsang WY, Khoo D, Dynlacht BD (August 2007). "Cep97 and CP110 suppress a cilia assembly program". Cell 130 (4): 678–90. doi:10.1016/j.cell.2007.06.027. PMID 17719545. 

Further reading[edit]