Pericentriolar material

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Pericentriolar material (PCM) is an amorphous mass of protein which makes up the part of the animal centrosome that surrounds the two centrioles. The PCM contains proteins responsible for microtubule nucleation and anchoring[1] including γ-tubulin, pericentrin and ninein.

According to the Gene Ontology, the following human proteins are associated with the PCM [1]:

  • BBS4, Bardet-Biedl syndrome 4 protein
  • Lck, Proto-oncogene tyrosine-protein kinase LCK
  • PCM1, Pericentriolar material 1 protein
  • TNKS, Tankyrase-1
  • TNKS2, Tankyrase-2
  • TUBE1, Tubulin epsilon chain

References[edit]

  1. ^ Eddé, B.; Rossier; Le Caer; Desbruyères; Gros; Denoulet (1990). "Posttranslational glutamylation of alpha-tubulin". Science 247 (4938): 83–85. Bibcode:1990Sci...247...83E. doi:10.1126/science.1967194. PMID 1967194.  edit