IL17RD

IL17RD
Identifiers
Aliases	IL17RD, HH18, IL-17RD, IL17RLM, SEF, interleukin 17 receptor D
External IDs	OMIM: 606807 MGI: 2159727 HomoloGene: 9717 GeneCards: IL17RD
Gene location (Human) Chr. Chromosome 3 (human) Band 3p14.3 Start 57,089,982 bp End 57,170,306 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 A3 Start 26,760,898 bp End 26,829,243 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte lactiferous duct ganglionic eminence corpus epididymis parietal pleura germinal epithelium sperm endothelial cell saphenous vein myometrium Top expressed in primitive streak Bowman's capsule secondary oocyte maxillary prominence ciliary body trigeminal ganglion aortic valve abdominal wall retinal pigment epithelium iris More reference expression data BioGPS n/a
Gene ontology Molecular function interleukin-17 receptor activity Cellular component cytoplasm integral component of membrane Golgi apparatus membrane Golgi membrane plasma membrane integral component of plasma membrane nucleoplasm Biological process MAPK cascade cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54756 171463 Ensembl ENSG00000144730 ENSMUSG00000040717 UniProt Q8NFM7 Q8JZL1 RefSeq (mRNA) NM_017563 NM_001318864 NM_027265 NM_134437 RefSeq (protein) NP_001305793 NP_060033 NP_602319 Location (UCSC) Chr 3: 57.09 – 57.17 Mb Chr 14: 26.76 – 26.83 Mb PubMed search
Wikidata
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Interleukin 17 receptor D is a protein that in humans is encoded by the IL17RD gene.

Function

This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms.

Further reading

• Kovalenko D, Yang X, Nadeau RJ, Harkins LK, Friesel R (2003). "Sef inhibits fibroblast growth factor signaling by inhibiting FGFR1 tyrosine phosphorylation and subsequent ERK activation". J. Biol. Chem. 278 (16): 14087–91. doi:10.1074/jbc.C200606200. PMID 12604616.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.