Interleukin-4 receptor

Interleukin 4 receptor
PDB rendering based on 1iar.
Available structures PDB 1IAR, 1IRS, 1ITE, 3BPL, 3BPN, 3BPO
Identifiers
Symbols	IL4R; CD124; IL4RA
External IDs	OMIM: 147781 MGI: 105367 HomoloGene: 7784 GeneCards: IL4R Gene
Gene Ontology Molecular function • receptor activity • interleukin-4 receptor activity • receptor signaling protein activity • protein binding • identical protein binding • insulin receptor substrate binding Cellular component • extracellular region • extracellular space • plasma membrane • integral to plasma membrane Biological process • production of molecular mediator involved in inflammatory response • immune response • signal transduction • interleukin-4-mediated signaling pathway • regulation of cell proliferation • positive regulation of macrophage activation • negative regulation of T-helper 1 cell differentiation • positive regulation of T-helper 2 cell differentiation • positive regulation of chemokine secretion Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3566	16190
Ensembl	ENSG00000077238	ENSMUSG00000030748
UniProt	P24394	Q3U905
RefSeq (mRNA)	NM_000418.2	NM_001008700.3
RefSeq (protein)	NP_000409.1	NP_001008700.1
Location (UCSC)	Chr 16: 27.33 – 27.38 Mb	Chr 7: 132.7 – 132.72 Mb
PubMed search	[1]	[2]

Interleukin-4 receptor alpha chain, N-terminal

interleukin-4 / receptor alpha chain complex
Identifiers
Symbol	IL4Ra_N
Pfam	PF09238
InterPro	IPR015319
SCOP	1iar
SUPERFAMILY	1iar
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.

See also

• Cluster of differentiation

Interactions

Interleukin-4 receptor has been shown to interact with SHC1.

Structure

The N-terminal (extracellular) portion of interleukin-4 is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.

Further reading

• Nelms K, Keegan AD, Zamorano J, et al. (1999). "The IL-4 receptor: signaling mechanisms and biologic functions.". Annu. Rev. Immunol. 17 (1): 701–38. doi:10.1146/annurev.immunol.17.1.701. PMID 10358772. 
• Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136. 

External links

• MeSH CD124+Antigen

This article incorporates text from the public domain Pfam and InterPro IPR015319