Interleukin-23 receptor

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Interleukin 23 receptor
Identifiers
Symbol IL23R
External IDs OMIM607562 MGI2181693 HomoloGene16930 GeneCards: IL23R Gene
Orthologs
Species Human Mouse
Entrez 149233 209590
Ensembl ENSG00000162594 ENSMUSG00000049093
UniProt Q5VWK5 Q8K4B4
RefSeq (mRNA) NM_144701 NM_144548
RefSeq (protein) NP_653302 NP_653131
Location (UCSC) Chr 1:
67.63 – 67.73 Mb
Chr 6:
67.42 – 67.49 Mb
PubMed search [1] [2]

Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene.[1]

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.[1]

Clinical significance[edit]

Mutations in the IL23R gene were linked to Crohn's disease.[2]

References[edit]

  1. ^ a b "Entrez Gene: IL23R interleukin 23 receptor". 
  2. ^ Diegelmann, J.; Czamara, D.; Le Bras, E.; Zimmermann, E.; Olszak, T.; Bedynek, A.; Göke, B.; Franke, A. et al. (2013). "Intestinal DMBT1 expression is modulated by Crohn's disease-associated IL23R variants and by a DMBT1 variant which influences binding of the transcription factors CREB1 and ATF-2.". PLoS One 8 (11): e77773. doi:10.1371/journal.pone.0077773. PMID 24223725. 

Further reading[edit]