Interleukin-23 receptor

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Interleukin 23 receptor
Identifiers
Symbol IL23R
External IDs OMIM607562 MGI2181693 HomoloGene16930 IUPHAR: 1717 GeneCards: IL23R Gene
Orthologs
Species Human Mouse
Entrez 149233 209590
Ensembl ENSG00000162594 ENSMUSG00000049093
UniProt Q5VWK5 Q8K4B4
RefSeq (mRNA) NM_144701 NM_144548
RefSeq (protein) NP_653302 NP_653131
Location (UCSC) Chr 1:
67.63 – 67.73 Mb
Chr 6:
67.42 – 67.49 Mb
PubMed search [1] [2]

Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene.[1]

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.[1]

Clinical significance[edit]

Mutations in the IL23R gene were linked to Crohn's disease.[2]

Model organisms[edit]

Model organisms have been used in the study of IL23R function. A conditional knockout mouse line called Il23rtm2a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[3] Male and female animals underwent a standardized phenotypic screen[4] to determine the effects of deletion.[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping[9]



References[edit]

  1. ^ a b "Entrez Gene: IL23R interleukin 23 receptor". 
  2. ^ Diegelmann, J.; Czamara, D.; Le Bras, E.; Zimmermann, E.; Olszak, T.; Bedynek, A.; Göke, B.; Franke, A. et al. (2013). "Intestinal DMBT1 expression is modulated by Crohn's disease-associated IL23R variants and by a DMBT1 variant which influences binding of the transcription factors CREB1 and ATF-2.". PLoS One 8 (11): e77773. doi:10.1371/journal.pone.0077773. PMID 24223725. 
  3. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Opthalmologica 88: 925-7.doi:10.1111/j.1755-3768.2010.4142.x: Wiley. 
  4. ^ a b "International Mouse Phenotyping Consortium". 
  5. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V et al. (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  6. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  7. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  8. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN et al. (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMID 23870131. 
  9. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium". 

Further reading[edit]