Interleukin-6 receptor

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Interleukin 6 receptor

PDB rendering based on 1n26.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols IL6R ; CD126; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ; gp80
External IDs OMIM147880 MGI105304 HomoloGene474 GeneCards: IL6R Gene
RNA expression pattern
PBB GE IL6R 205945 at tn.png
PBB GE IL6R 217489 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3570 16194
Ensembl ENSG00000160712 ENSMUSG00000027947
UniProt P08887 P22272
RefSeq (mRNA) NM_000565 NM_010559
RefSeq (protein) NP_000556 NP_034689
Location (UCSC) Chr 1:
154.38 – 154.44 Mb
Chr 3:
89.87 – 89.91 Mb
PubMed search [1] [2]

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

In melanocytic cells IL6R gene expression may be regulated by MITF.[1]

Structure[edit]

The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2] IL6R subunit is also shared by many other cytokines.

Interactions[edit]

Interleukin-6 receptor has been shown to interact with Interleukin 6[3] [4] [5] and Ciliary neurotrophic factor.[4][6]

See also[edit]

References[edit]

  1. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 
  2. ^ "Entrez Gene: IL6R interleukin 6 receptor". 
  3. ^ Schwantner, Andreas; Dingley Andrew J, Ozbek Suat, Rose-John Stefan, Grötzinger Joachim (Jan 2004). "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". J. Biol. Chem. (United States) 279 (1): 571–6. doi:10.1074/jbc.M311019200. ISSN 0021-9258. PMID 14557255. 
  4. ^ a b Schuster, Björn; Kovaleva Marina, Sun Yi, Regenhard Petra, Matthews Vance, Grötzinger Joachim, Rose-John Stefan, Kallen Karl-Josef (Mar 2003). "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. (United States) 278 (11): 9528–35. doi:10.1074/jbc.M210044200. ISSN 0021-9258. PMID 12643274. 
  5. ^ Taga, T; Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T (Aug 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell (UNITED STATES) 58 (3): 573–81. doi:10.1016/0092-8674(89)90438-8. ISSN 0092-8674. PMID 2788034. 
  6. ^ Schooltink, H; Stoyan T, Roeb E, Heinrich P C, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. (NETHERLANDS) 314 (3): 280–4. doi:10.1016/0014-5793(92)81489-9. ISSN 0014-5793. PMID 1281789. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.