Alpha-taxilin

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Taxilin alpha
Identifiers
Symbols TXLNA ; IL14; TXLN
External IDs OMIM608676 MGI105968 HomoloGene14062 GeneCards: TXLNA Gene
RNA expression pattern
PBB GE TXLNA 212300 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 200081 109658
Ensembl ENSG00000084652 ENSMUSG00000053841
UniProt P40222 Q6PAM1
RefSeq (mRNA) NM_175852 NM_001005506
RefSeq (protein) NP_787048 NP_001005506
Location (UCSC) Chr 1:
32.65 – 32.66 Mb
Chr 4:
129.63 – 129.64 Mb
PubMed search [1] [2]

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.[1][2][3]

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells.[4] This molecule was also recently designated taxilin.[5] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.

Gene[edit]

Two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.[6] The il14 locus is near the gene for LCK on chromosome 1 in humans.

References[edit]

  1. ^ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072. 
  2. ^ Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. doi:10.1016/j.bbrc.2003.10.069. PMID 14623251. 
  3. ^ "Entrez Gene: TXLNA taxilin alpha". 
  4. ^ Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. doi:10.1073/pnas.90.13.6330. PMC 46922. PMID 8327514. 
  5. ^ Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells 8 (1): 17–28. doi:10.1046/j.1365-2443.2003.00612.x. PMID 12558796. 
  6. ^ Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. PMID 17015757. 

Further reading[edit]