Interleukin 14
From Wikipedia, the free encyclopedia
Interleukin-14 (IL-14) is a cytokine that is also called High molecular weight B-cell growth factor (HMW-BCGF) that controls the growth and proliferation of both normal and cancerous B cells.[1] This molecule was also recently designated taxilin.[2] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.
Two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.[3] The il14 locus is near the gene for LCK on chromosome 1 in humans.
IL14 interleukin 14 [ Homo sapiens ] Gene ID: 3599, discontinued on 10-May-2005. GeneID was defined by L15344.1, which aligns on the strand opposite to TXLNA, alpha taxilin.[4]
[edit] References
- ^ Ambrus JL et al., Identification of a cDNA for a human high-molecular-weight B-cell growth factor., 1993, Proceedings of the National Academy of Sciences USA, Volume 90, pages 6330-4.
- ^ Nogami,S et al., Taxilin; a novel syntaxin-binding protein that is involved in Ca2+- dependent exocytosis in neuroendocrine cells. Genes Cells, 2003, Volume 8, pages 17-28
- ^ Shen, L. et al., Development of Autoimmunity in IL-14-Transgenic Mice. The Journal of Immunology, 2006, Volume 177, pages 5676-5686.
- ^ http://www.ncbi.nlm.nih.gov/gene/3599
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IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21, IFNB1, IFNK, IFNW1
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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