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Taxilin alpha
Symbols TXLNA ; IL14; TXLN
External IDs OMIM608676 MGI105968 HomoloGene14062 GeneCards: TXLNA Gene
RNA expression pattern
PBB GE TXLNA 212300 at tn.png
More reference expression data
Species Human Mouse
Entrez 200081 109658
Ensembl ENSG00000084652 ENSMUSG00000053841
UniProt P40222 Q6PAM1
RefSeq (mRNA) NM_175852 NM_001005506
RefSeq (protein) NP_787048 NP_001005506
Location (UCSC) Chr 1:
32.65 – 32.66 Mb
Chr 4:
129.63 – 129.64 Mb
PubMed search [1] [2]

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene.[1][2][3]

Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells.[4] This molecule was also recently designated taxilin.[5] IL-14 induces B-cell proliferation, inhibits antibody secretion, and expands selected B-cell subgroups. This interleukin is produced mainly by T cells and certain malignant B cells.


In murine models, two distinct transcripts are produced from opposite strands of the il14 gene that are called IL-14α and IL-14β.[6] The il14 locus is near the gene for LCK on chromosome 1 in humans.


  1. ^ Nogami S, Satoh S, Tanaka-Nakadate S, Yoshida K, Nakano M, Terano A, Shirataki H (Jun 2004). "Identification and characterization of taxilin isoforms". Biochem. Biophys. Res. Commun. 319 (3): 936–43. doi:10.1016/j.bbrc.2004.05.073. PMID 15184072. 
  2. ^ Nogami S, Satoh S, Nakano M, Terano A, Shirataki H (Nov 2003). "Interaction of taxilin with syntaxin which does not form the SNARE complex". Biochem. Biophys. Res. Commun. 311 (4): 797–802. doi:10.1016/j.bbrc.2003.10.069. PMID 14623251. 
  3. ^ "Entrez Gene: TXLNA taxilin alpha". 
  4. ^ Ambrus JL, Pippin J, Joseph A, Xu C, Blumenthal D, Tamayo A, Claypool K, McCourt D, Srikiatchatochorn A, Ford RJ (July 1993). "Identification of a cDNA for a human high-molecular-weight B-cell growth factor". Proc. Natl. Acad. Sci. U.S.A. 90 (13): 6330–4. doi:10.1073/pnas.90.13.6330. PMC 46922. PMID 8327514. 
  5. ^ Nogami S, Satoh S, Nakano M, Shimizu H, Fukushima H, Maruyama A, Terano A, Shirataki H (January 2003). "Taxilin; a novel syntaxin-binding protein that is involved in Ca2+-dependent exocytosis in neuroendocrine cells". Genes Cells 8 (1): 17–28. doi:10.1046/j.1365-2443.2003.00612.x. PMID 12558796. 
  6. ^ Shen L, Zhang C, Wang T, Brooks S, Ford RJ, Lin-Lee YC, Kasianowicz A, Kumar V, Martin L, Liang P, Cowell J, Ambrus JL (October 2006). "Development of autoimmunity in IL-14alpha-transgenic mice". J. Immunol. 177 (8): 5676–86. PMID 17015757. 

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