Originally, the Seminoles and Miccosukee were part of the Creek Confederacy, until they began to migrate to Florida after contact with the Spanish. The Indian Wars of the 19th Century greatly depleted the numbers of these tribes, specifically the Second Seminole War. From this, only about 300-500 remained in Florida, moving to the Everglades. From here, the Seminoles split apart from the Miccosukee, with the former moving on reservations and the latter living along the Tamiami Trail. Though the tribes are federally recognized as being distinct, both have speakers of Mikasuki.
As of 2002, the language was taught in the local school, which had "an area devoted to 'Miccosukee Language Arts'".
As of 2011, the University of Florida Department of Anthropology is home to The Elling Eide Endowed Professorship in Miccosukee Language and Culture, for Native American languages of the southeastern United States.
Mikasuki is written using the Latin alphabet. The vowels are pronounced as follows:
The consonants are:
High tone is indicated with an acute, low tone with a grave and falling tone with an acute (on a long vowel this is typographically split over both vowels, otherwise the grave is placed over the next consonant):
An epenthetic [ə] vowel appears in kl, kw and kn clusters in careful speech.