NACHT, LRR and PYD domains-containing protein 1 is a protein that in humans is encoded by the NLRP1gene.
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
^ abChu, Z L; Pio F, Xie Z, Welsh K, Krajewska M, Krajewski S, Godzik A, Reed J C (Mar 2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis". J. Biol. Chem. (United States) 276 (12): 9239–45. doi:10.1074/jbc.M006309200. ISSN0021-9258. PMID11113115.Cite uses deprecated parameters (help)
^Hlaing, T; Guo R F, Dilley K A, Loussia J M, Morrish T A, Shi M M, Vincenz C, Ward P A (Mar 2001). "Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins". J. Biol. Chem. (United States) 276 (12): 9230–8. doi:10.1074/jbc.M009853200. ISSN0021-9258. PMID11076957.Cite uses deprecated parameters (help)
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res.6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID10231032.
Hlaing T, Guo RF, Dilley KA, et al. (2001). "Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins.". J. Biol. Chem.276 (12): 9230–8. doi:10.1074/jbc.M009853200. PMID11076957.
Chu ZL, Pio F, Xie Z, et al. (2001). "A novel enhancer of the Apaf1 apoptosome involved in cytochrome c-dependent caspase activation and apoptosis.". J. Biol. Chem.276 (12): 9239–45. doi:10.1074/jbc.M006309200. PMID11113115.
Martinon F, Hofmann K, Tschopp J (2001). "The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation.". Curr. Biol.11 (4): R118–20. doi:10.1016/S0960-9822(01)00056-2. PMID11250163.