Phenprocoumon

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Phenprocoumon
Phenprocoumon.svg
Systematic (IUPAC) name
(RS)-4-hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one
Clinical data
Trade names Marcoumar, Marcumar, Falithrom
AHFS/Drugs.com International Drug Names
MedlinePlus a699003
Legal status Prescription only
Pharmacokinetic data
Protein binding 99%
Metabolism hepatic to inactive metabolites
Half-life 5 to 6 days
Identifiers
CAS number 435-97-2 YesY
ATC code B01AA04
PubChem CID 9908
DrugBank DB00946
ChemSpider 10441592 YesY
UNII Q08SIO485D YesY
KEGG D05457 YesY
ChEBI CHEBI:50438 YesY
ChEMBL CHEMBL1465 YesY
Chemical data
Formula C18H16O3 
Mol. mass 280.318 g/mol
 YesY (what is this?)  (verify)

Phenprocoumon (marketed under the brand names Marcoumar, Marcumar and Falithrom) is a long-acting oral anticoagulant drug, a derivative of coumarin. It is a vitamin K antagonist that inhibits coagulation by blocking synthesis of coagulation factors II, VII, IX and X. It is used for the prophylaxis and treatment of thromboembolic disorders (thrombosis/pulmonary embolism). It is the standard coumarin used in Germany.

Phenprocoumon is a 4-hydroxycoumarin and inhibits vitamin K epoxide reductase.[1]

References[edit]

  1. ^ Phenprocoumon at PharmGKB

External links[edit]