Strictosidine beta-glucosidase

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3alpha(S)-strictosidine beta-glucosidase
EC number
CAS number 73379-57-4
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3alpha(S)-strictosidine beta-glucosidase (EC is an enzyme with systematic name strictosidine beta-D-glucohydrolase.[1][2][3] This enzyme catalyses the following chemical reaction

strictosidine + H2O D-glucose + strictosidine aglycone

Thus, the two substrates of this enzyme are strictosidine and H2O, whereas its two products are D-glucose and strictosidine aglycone.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. This enzyme participates in indole and ipecac alkaloid biosynthesis.

Strictosidine is a precursor of indole alkaloids.


  1. ^ Hemscheidt, T.; Zenk, M.H. (1980). "Glucosidases involved in indole alkaloid biosynthesis of Catharanthus cell cultures". FEBS Lett. 110: 187–191. PMID 6768587. doi:10.1016/0014-5793(80)80069-X. 
  2. ^ Luijendijk T.J.C.; Stevens L.H.; Verpoorte R. (1998). "Purification and characterisation of strictosidine beta-D-glucosidase from Catharanthus roseus cell suspension cultures". Plant Physiol. Biochem. 36: 419–425. doi:10.1016/S0981-9428(98)80205-2. 
  3. ^ Barleben, L.; Ma, X.; Koepke, J.; Peng, G.; Michel, H.; Stöckigt, J. (2005). "Expression, purification, crystallization and preliminary X-ray analysis of strictosidine glucosidase, an enzyme initiating biosynthetic pathways to a unique diversity of indole alkaloid skeletons". Biochim. Biophys. Acta. 1747: 89–92. PMID 15680242. doi:10.1016/j.bbapap.2004.09.026. 

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