Glucosylceramidase tetramer, Human
|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- D-glucosyl-N-acylsphingosine + H2O D-glucose + N-acylsphingosine
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include:
- psychosine hydrolase,
- glucosphingosine glucosylhydrolase,
- ceramide glucosidase,
- glucosylsphingosine beta-glucosidase,
- and glucosylsphingosine beta-D-glucosidase.
Human proteins containing this domain
- Brady RO, Kanfer J, Shapiro D (1965). "The metabolism of glucocerebrosides: I. Purification and properties of a glucocerebroside-cleaving enzyme from spleen tissue". J. Biol. Chem. 240: 39–43.
- Vaccaro AM, Muscillo M, Suzuki K (1985). "Characterization of human glucosylsphingosine glucosyl hydrolase and comparison with glucosylceramidase". Eur. J. Biochem. 146 (2): 315–21. doi:10.1111/j.1432-1033.1985.tb08655.x. PMID 3967661.
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