Doramectin
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Injection, Topical and Oral |
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| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.123.125 |
| Chemical and physical data | |
| Formula | C50H74O14 |
| Molar mass | 899.114 g·mol−1 |
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Doramectin (Dectomax) is a veterinary drug approved by the Food and Drug Administration (FDA) for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.[1]
It is used for the treatment and control of internal parasitosis (gastrointestinal and pulmonary nematodes), ticks and mange (and other ectoparasites). Doramectin is a derivative of ivermectin. Similarly to other drugs of this family, it is produced by fermentation by selected strains of Streptomyces avermitilis.[2][3] Its spectrum includes: Haemonchus, Ostertagia, Trichostrongylus, Cooperia, and Oesophagostomum species and Dictyocaulus viviparus, Dermatobia hominis, Boophilus microplus, and Psoroptes bovis, among many other internal and external parasites. It is available as an injection and as a 5-mg/ml topical solution.
Doramectin is also marketed in many Latin-American and some Asia and Africa countries as Doramec L.A. (manufactured by Agrovet Market Animal Health[4]) in a 1% Doramectin Long Acting Injectable Solution for cattle, sheep, swine[5] and others. Its oleous carrier confers to Doramec L.A. a slow and prolonged liberation, extending its action up to 42 days.
Doramectin is also available for horses[5] as an oral, flavored, bioadhesive gel under the name Doraquest L.A. Oral Gel.[6] It can be used to control and treat internal parasites as roundworms, lungworms and some external parasites.
References
- ^ Pfizer Animal Health. "DECTOMAX Injectable." Archived August 14, 2007, at the Wayback Machine Last accessed July 14, 2007.
- ^ Dectomax product information (Zoetis US)
- ^ Goudie AC, Evans NA, Gration KA, Bishop BF, Gibson SP, Holdom KS, Kaye B, Wicks SR, Lewis D, Weatherley AJ (July 1993). "Doramectin--a potent novel endectocide". Veterinary Parasitology. 49 (1): 5–15. doi:10.1016/0304-4017(93)90218-c. PMID 8236738.
- ^ Agrovet Market Animal Health-Doramec L.A.
- ^ a b Agrovet Market Animal Health
- ^ Agrovet Market Animal Health-Doraquest L.A. Oral Gel