OR10H4

OR10H4
Identifiers
Aliases	OR10H4, OR19-28, olfactory receptor family 10 subfamily H member 4
External IDs	MGI: 1335096; HomoloGene: 113739; GeneCards: OR10H4; OMA:OR10H4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.12 Start 15,944,299 bp End 15,950,350 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 B1 Start 33,483,650 bp End 33,494,618 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ventricle n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity neurotransmitter receptor activity G protein-coupled serotonin receptor activity molecular function Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane dendrite Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell signal transduction response to stimulus G protein-coupled serotonin receptor signaling pathway G protein-coupled receptor signaling pathway biological process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 126541 258939 Ensembl ENSG00000176231 ENSMUSG00000054666 UniProt Q8NGA5 Q8VBW9 RefSeq (mRNA) NM_001004465 NM_146937 RefSeq (protein) NP_001004465 NP_667148 Location (UCSC) Chr 19: 15.94 – 15.95 Mb Chr 17: 33.48 – 33.49 Mb PubMed search
Wikidata
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Olfactory receptor 10H4 is a protein that in humans is encoded by the OR10H4 gene.

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes" (PDF). Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

• OR10H4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.