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Fluclorolone

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Not to be confused with Fluclorolone acetonide or Fluocortolone.
Fluclorolone
Clinical data
Other names6α-Fluoro-9α,11β-dichloro-16α,17α,21-trihydroxypregna-1,4-diene-3,20-dione
Drug classCorticosteroid; Glucocorticoid
Identifiers
  • (6S,8S,9R,10S,11S,13S,14S,16R,17S)-9,11-Dichloro-6-fluoro-16,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC21H25Cl2FO5
Molar mass447.32 g·mol−1
3D model (JSmol)
  • C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@H]([C@@]2(C(=O)CO)O)O)C[C@@H](C4=CC(=O)C=C[C@@]43C)F)Cl)Cl
  • InChI=1S/C21H25Cl2FO5/c1-18-4-3-10(26)5-13(18)14(24)6-12-11-7-16(27)21(29,17(28)9-25)19(11,2)8-15(22)20(12,18)23/h3-5,11-12,14-16,25,27,29H,6-9H2,1-2H3/t11-,12-,14-,15-,16+,18-,19-,20-,21-/m0/s1
  • Key:VTWKPILBIUBMDS-OTJLYDAYSA-N

Fluclorolone is a synthetic glucocorticoid corticosteroid which was never marketed.[1][2] The acetonide cyclic ketal of fluclorolone, fluclorolone acetonide, in contrast, has been marketed.[1][2]

References

  1. ^ a b Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 557–. ISBN 978-1-4757-2085-3.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 448–. ISBN 978-3-88763-075-1.



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